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MPFF is Supported by Clinical Evidence

2011 Gloviczki P, et al. J Vasc Surg, May Supplement 2011

The care of patients with varicose veins and associated chronic venous diseases: Clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum*

Article guidelines recommend:

  1. Diosmin and hesperidin as MPFF in addition to compression for patients with pain and swelling due to chronic venous disease.
  2. Diosmin and hesperidin as MPFF in combination with compression, to accelerate healing of venous ulcers.
* This reference is not an endorsement of Vein Formula.
2013 Perera N, et al. Cochrane Database Syst Rev. 2012;8

Phlebotonics for hemorrhoids – Cochrane Database of Systematic Reviews – Perera – Wiley Online Library*

Authors’ conclusions:

There is a potential benefit in using phlebotonics in treating hemorrhoidal disease as well as a benefit in alleviating post- hemorrhoidectomy symptoms.

* This reference is not an endorsement of Vein Formula.
2014 O’Donnell F, et al. J Vasc Surg 2014

Management of venous leg ulcers: Clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum*

Endorsed by The American College of Phlebology and The Union Internationale de Phlebologie*.

Article guidelines recommend:

For long-standing or large venous ulcer, treatment with micronized purified flavonoid fraction used in combination with compression therapy.

* This reference is not an endorsement of Vein Formula.
2015 Wittens C, et al. Eur J Vasc Endovasc Surg 2015

Editor’s Choice – Management of Chronic Venous Disease – Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS)*

Article guidelines recommend:

  1. MPFF should be considered as a treatment option for swelling and pain caused by chronic venous disease.
  2. MPFF should be considered as an adjuvant to compression therapy in patients with venous ulcers.
* This reference is not an endorsement of Vein Formula.
2017 Gloviczki P, et al. 2017

Handbook of Venous and Lymphatic Disorders – Fourth Edition – Guidelines of the American Venous Forum*

Handbook guidelines recommend:

  1. Diosmin and hesperidin as MPFF for symptomatic patients and those with swelling secondary to CVI.
  2. MPFF for patients with venous ulceration.
* This reference is not an endorsement of Vein Formula.